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What is Behind the Fatigue Concept? (Friedl, 2007)
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The Case for Using Probabilistic Knowledge in a Computer Chess Program (John L. Jerz)
Resilience in Man and Machine

 
This brief article is a very good introduction to the concept of stressors, coping, resilience, and fatigue, to those not familiar with the concepts. The problems faced by an agent playing a game and a commander fighting a war are similar.
 
Friedl suggests the interesting idea that there are countermeasures to fatigue, including 'prehabilitation' of areas likely to become damaged.

Excerpts:
 
ABSTRACT

Fatigue is the state of reduced human performance capability caused by an inability to continue to cope with physiological stressors.  This paper provides examples in an overview of current work on mechanisms of fatigue and interventions to sustain performance in military operations.  At least six categories of militarily-relevant fatigue can be described:  intensively demanding tasks (“overtraining” or “overload”), prolonged wakefulness, circadian disruptions, psychosocial distractors, environmental strain, and metabolic limiters.  There are at least three major categories of mechanisms of the performance degradation: insufficient fuel, damage or pre-damage afferent limiters, and central mechanisms.  Sophisticated scientific investigations of potential Interventions must provide practical and affordable solutions.  Affordable near term potential countermeasures include:  training to build resilience, rest and recovery strategies, “pre-habilitation”(physical therapy in advance of failure), nutrition and dietary supplements, pharmaceuticals, assistive technologies, and “mindfulness” training.
 
Fatigue is such a useful word that the English language has borrowed it from the French.  For this paper, the word is defined as “the state of reduced human performance capability due to inability to continue to cope with physiological stressors.”  Stressors are any challenges to the organism that evoke a response.  They may be external (e.g., ambient heat, cold, hypoxia) or internal (e.g., metabolic, perceived psychological threats, illness).  Coping is the set of responses that sustain performance in the presence of stressors.  Resilience is the relative assessment of coping agility. 
 
4.0 Practical Countermeasures to fatigue... Training to build resilience
 
General research barriers still limit this work, regardless of the stressor, mechanism, or proposed countermeasure.  Fundamental to all of this effort is a clear definition of practical measures of performance that can be used to determine when and how performance is degraded and the effectiveness of countermeasures.  Another key barrier is the determination of individual variability in response to stressors and interventions. 

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