p.4 Why do we get stressed out? Surely the last thing we need when times are tough is to complicate
things even further by developing physical or mental illness. So why does the human organism contain a provision for causing
illness under duress? The answer, of course, is that causing illness is not the function of the stress response. Rather, the
fight-or-flight response evolved with the prime directive of ensuring our safety and survival. It's a powerful
system, a dynamic resilience that sharpens our attention and mobilizes our bodies to cope with threatening situations,
then returns to baseline, usually with no ill effects. Only when it's overwhelmed or derailed does the stress response system
begin to cause disease.
This book was written to emphasize the following paradox: stress protects under acute conditions,
but when activated chronically it can cause damage and accelerate disease.
p.7 Remember, the purpose of allostasis [JLJ - often thought of as the fight-or-flight
response] is to help the organism remain stable in the face of any change and to provide enough energy to cope with any challenge
- not just life-threatening ones.
p.7-8 deprived of its natural result, the very system designed to protect us begins to cause wear and tear
instead... This is the type of stress, or the state of being stressed out, that I prefer to describe as allostatic load -
the damage that the allostatic response causes when it is functioning improperly... Allostatic load is like two sumo
wrestlers on a seesaw - the seesaw may be in balance, but it's under a strain that may eventually cause it to break.
p.12 Selye began to experiment... Every type of irritant produced the same constellation of responses. Why?
Why should the the body react in the same way to unrelated or even opposite kinds of stimuli? The evidence was strong that
the body must have a consistent, organized mechanism to help cope with a variety of insults. Selye dubbed the mechanism the
general adaptation syndrome
p.12-13 If we could prove that the organism had a general nonspecific reaction-pattern with which it could
meet damage caused by a variety of potential disease-producers, this defensive response would lend itself to a strictly objective,
truly scientific analysis. By clarifying the function of the mechanism of response through which Nature herself fights injuries
of various kinds, we might learn how to improve upon this reaction whenever it is imperfect.
p.13 Selye's research appeared in the journal Nature on July 4, 1936, as a 74-line note entitled "A Syndrome
Produced by Diverse Nocuous Agents." His next step was to find a better name for his discovery than general adaptation syndrome...
Eventually he hit on the word stress.
p.40 I have made the claim that stress begins in the brain... the scientists of Selye's day did not accept
the brain as the master coordinator of the stress response. One might argue that stress has to begin in the brain. For
the physiological mechanisms of fight or flight to be successfully sprung, an animal has to first perceive the intruder -
by seeing, smelling, or hearing it - then call up past experience to decide whether to decide to run away or prepare to dine...
a process associated with the brain nonetheless.
p.66 With so many ways of going wrong, it may sound as if the fight-or-flight response is a fragile thing,
but actually it's quite resilient
p.201 The "altered state" of allostasis [JLJ - often thought of as the fight-or-flight
response] occurs when a short-term or "acute" response is not sufficient to produce a long-term "adaptive" response.